Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
Follistatin 344 has some truly remarkable benefits associated with it. These effects are why bodybuilders and athletes use Follistatin.
Follistatin 344 is very popular because it helps put on lean muscle. This is particularly important for bodybuilders who usually want lean muscle as their objective is to have an aesthetically pleasing body. The only size is not as important, as size along with less fat is.
Saves from effects of myostatin Myostatin is a protein which is called as growth differentiation factor. Or put in different words it stops the body from putting on muscle mass beyond a certain threshold. Without it, humans can put on one to two pounds of muscle a day. It may also cause skeletal muscle fibrosis, impair tissue function, and causes chronic diseases in organs, tissues, and bone marrow. Follistatin 344 is a myostatin inhibitor and suppresses the effects of myostatin.
Follicle Stimulating Hormone or FSH is synthesized and secreted by the pituitary gland. An excess of FSH in men leads to the testicles not working properly. It limits muscle growth, recovery, and normal hormone function. Follistatin 344 helps to suppress the synthesis and secretion of FSH. However, it should be noted that if the levels of FSH fall too low then they can have an adverse effect. https://jonabiotech.com/
Many performance enhancers and myostatin inhibitors are required to be taken on a regular basis. A lot of times they have to be cycled in order to ensure that they do not cause harm to the user. However, Follistatin 344 is different in this respect. Elevated levels of Follistatin 344 were found in the body as later as fifteen months after the first injection. This proves that Follistatin 344 can be used as a long-term enhancer.
Follistatin 344 comes in powdered form and has to be reconstituted i.e. mixed with a suitable diluent before it can be used. Once mixed, it must be stored in the fridge and used within seven days.
Follistatin is taken via an injection into the muscle that you wish to build. Follistatin 344 should be cycled over a period of ten days. Though one ten-day cycle can work effectively for three months. One dosage of Follistatin 344 can be anywhere between 100 to 300 micrograms. Different athletes have different experiences with the dosage, and you should tweak it according to your body, and not just follow others experience.
Also, it has been suggested to add peptides along with Follistatin 344 in order to improve the results. Some of the peptides that can be added or stacked are IGF-1 DES, MGF, Ostarine, Hexarelin, Ipamoreline and GHRP-6.
Follistatin side effects
While myostatin does stop the body from putting on muscle, it is not without use. Myostatin is extremely important from the perspective of repairing and maintaining tendons and ligaments. A fall in myostatin causes damage, albeit temporarily, to tendons and ligaments.