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Venclexta Side Effects:

Most common side effects of venetoclax are low blood cell count, fatigue, upper respiratory tract infection, diarrhea, anemia and low platelet count.

Some patients experience these major side effects like tumor lysis syndrome and severe low white blood cell count.

Male patients on venetoclax sometimes can experience fertility problems.
What to avoid when taking Venclyxto?

The following will increase venetoclax/Venclexta in your blood:

Grapefruit
Grapefruit juice
Seville oranges (often used in marmalade)
Starfruit

What is the patient profile of chronic lymphocytic leukemia or CLL?

CLL accounts for 37% of all cases of leukemia in adults. The average age of a patient diagnosed with CLL is 70 years of age, more common in older adults. 12,990 men and 7,950 women will be diagnosed for CLL this year.
What is the patient survival rate after diagnosis of chronic lymphocytic leukemia or CLL?

Compared to other cancers CLL has a higher survival rate. On average a CLL patient after diagnosis will be alive for 5 years. However, some patients may live longer due to on and off treatment because CLL recurs.
Venetoclax Important Safety Information & Uses
What is the most important information I should know about VENCLEXTA?

VENCLEXTA can cause serious side effects, including:

{Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure, the need for dialysis treatment, and may lead to death. Your healthcare provider will do tests to check your risk of getting TLS before you start taking VENCLEXTA. You will receive other medicines before starting and during treatment with VENCLEXTA to help reduce your risk of TLS.

You may also need to receive intravenous (IV) fluids into your vein. {Your healthcare provider will do blood tests to check for TLS when you first start treatment and during treatment with VENCLEXTA.|When you first start treatment and during treatment with VENCLEXTA, your healthcare provider will do blood tests to check for TLS.} It is important to keep your appointments for blood tests.

Tell your healthcare provider right away if you have any symptoms of TLS during treatment with VENCLEXTA, including fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, {dark or cloudy|cloudy or dark} urine, unusual tiredness, or muscle or joint pain.|Your healthcare provider will do tests to check your risk of getting TLS before you start taking VENCLEXTA.

Your healthcare provider will do blood tests to check for TLS when you first start treatment and during treatment with VENCLEXTA. Tell your healthcare provider right away if you have any symptoms of TLS during treatment with VENCLEXTA, including fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, {dark or cloudy|cloudy or dark} urine, unusual tiredness, or muscle or joint pain.} https://jonabiotech.com/

Drink plenty of water during treatment with VENCLEXTA to help reduce your risk of getting TLS. Drink 6 to 8 glasses (about 56 ounces total) of water each day, starting 2 days before your first dose, on the day of your first dose of VENCLEXTA, and each time your dose is increased.

Your healthcare provider may delay, decrease your dose, or stop treatment with VENCLEXTA if you have side effects.

The starting dose is 20 mg of venetoclax once daily for 7 days. The dose must be gradually increased over a period of 5 weeks up to the daily dose of 400 mg as shown in Table 1.

Table 1: Dose increase schedule